NODAL

Across TCGA cell cohorts, NODAL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,152 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NODAL-associated GO terms across cancer lineages are Negative regulation of mRNA metabolic process, Regulation of RNA splicing, and RNA catabolic process. Each is linked with NODAL in more than 14 cancer types. Because this analysis shows association rather than direction, both NODAL-to-partner and partner-to-NODAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA metabolic process grouped by NODAL-low versus NODAL-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NODAL→partner) and Y-score (partner→NODAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of mRNA metabolic process →	+0.103	+0.178	<.001	.008	3	15
BLOOD_Leukemia	Regulation of RNA splicing →	+0.049	+0.163	<.001	<.001	3	13
LUNG_NSCLC_LUSC	RNA catabolic process →	+0.053	+0.403	.001	.002	3	12
OESOPHAGUS	Regulation of myoblast fusion →	+0.113	+0.275	<.001	<.001	3	12
OESOPHAGUS	Positive regulation of double-strand break repair →	+0.075	+0.387	.004	.001	3	12
STOMACH	Regulation of nucleotide-excision repair →	+0.175	+0.183	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,152 associations by consensus.

Negative regulation of mRNA metabolic process by NODAL expression — STOMACH

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