NODAL

Across TCGA cell cohorts, NODAL mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible NODAL-associated genes across cancer lineages are SPATA48, PRM1, and KRTAP11-1. Each is linked with NODAL in more than 1 cancer types. Because this analysis shows association rather than direction, both NODAL-to-partner and partner-to-NODAL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA48 grouped by NODAL-low versus NODAL-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NODAL→partner) and Y-score (partner→NODAL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SPATA48 →	+0.013	+5.807	<.001	.001	3	1
OVARY	PRM1 →	+0.078	+5.196	<.001	.005	3	1
OVARY	KRTAP11-1 →	+0.139	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

SPATA48 by NODAL expression — OVARY

Explore this box plot interactively →