NOBOX

Across TCGA patient cohorts, NOBOX protein abundance is significantly associated with the protein abundance of many other proteins, with 4,426 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOBOX-associated proteins across cancer lineages are WDR76, ZFYVE9, and CYRIB. Each is linked with NOBOX in more than 1 cancer types. Because this analysis shows association rather than direction, both NOBOX-to-partner and partner-to-NOBOX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NOBOX versus WDR76 in LSCC, with a Pearson correlation of 0.73.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NOBOX→partner) and Y-score (partner→NOBOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR76 →	+0.900	+1.462	<.001	.005	3	1
LSCC	ZFYVE9 →	+0.455	+1.943	.002	.003	3	1
LSCC	CYRIB →	-0.435	-2.297	.008	.004	2	1
LSCC	EMC4 →	-0.383	-1.929	.002	.006	2	1
LSCC	ARHGEF28_S624 →	+1.115	+1.462	.002	.006	2	1
LSCC	VCPIP1 →	-0.400	-2.382	.001	.003	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,426 associations by consensus.

NOBOX vs WDR76 — LSCC

Explore this scatter interactively →