NOBOX

Across TCGA patient cohorts, NOBOX mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NOBOX-associated genes across cancer lineages are Caspase-7-cleavedD198, Cyclin-B1, and FASN. Each is linked with NOBOX in more than 2 cancer types. Because this analysis shows association rather than direction, both NOBOX-to-partner and partner-to-NOBOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by NOBOX-low versus NOBOX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOBOX→partner) and Y-score (partner→NOBOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.577	+1.720	.008	.025	3	3
LUAD	Cyclin-B1 →	+0.653	+3.169	.010	.019	3	2
LUAD	FASN →	+0.581	+3.169	.012	.019	2	2
LUAD	B-Raf →	+0.518	+3.186	.006	.010	3	1
UCEC	EGFR_pY1068 →	-0.217	-1.847	.018	.008	3	1
UCEC	eIF4E →	+0.157	+1.847	.043	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Caspase-7-cleavedD198 by NOBOX expression — UCEC

Explore this box plot interactively →