NOBOX

Across TCGA cell cohorts, NOBOX RNA expression is significantly associated with the mutation status of many other genes, with 114 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible NOBOX-associated genes across cancer lineages are ATR, PCLO, and DYNC1H1. Each is linked with NOBOX in more than 2 cancer types. Because this analysis shows association rather than direction, both NOBOX-to-partner and partner-to-NOBOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATR grouped by NOBOX-low versus NOBOX-high in LUNG_SCLC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOBOX→partner) and Y-score (partner→NOBOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ATR →	+2.263	+0.015	.003	.007	3	3
URINARY_TRACT	PCLO →	+3.459	+0.013	.002	<.001	3	2
LUNG_SCLC	DYNC1H1 →	+3.169	+0.023	.005	<.001	3	2
LUNG_NSCLC_LUSC	NOTCH2 →	+4.643	+0.040	.008	<.001	3	2
LUNG_NSCLC_LUSC	TOP3A →	+4.643	+0.040	.008	<.001	3	2
BLOOD_Leukemia	ZNF708 →	+5.539	+0.072	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

ATR by NOBOX expression — LUNG_SCLC

Explore this box plot interactively →