NOBOX

Across TCGA cell cohorts, NOBOX mutation is significantly associated with the RNA expression of many other genes, with 80 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible NOBOX-associated genes across cancer lineages are POLG, ASZ1, and GABRA6. Each is linked with NOBOX in more than 2 cancer types. Because this analysis shows association rather than direction, both NOBOX-to-partner and partner-to-NOBOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLG grouped by NOBOX-low versus NOBOX-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOBOX→partner) and Y-score (partner→NOBOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	POLG →	+0.428	+3.115	.007	.009	3	3
LUNG_NSCLC_LUSC	ASZ1 →	+0.089	+4.108	.008	.005	3	2
LUNG_SCLC	GABRA6 →	+0.071	+2.316	.003	.003	3	2
LUNG_NSCLC_LUSC	BSX →	+0.048	+4.108	<.001	.005	3	1
LUNG_SCLC	CENPA →	+0.517	+3.321	.009	.004	3	1
LUNG_SCLC	GTDC1 →	+0.725	+3.321	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 80 associations by consensus.

POLG by NOBOX expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →