NNMT

Across TCGA patient cohorts, NNMT mutation is significantly associated with the RNA expression of many other genes, with 2,446 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NNMT-associated genes across cancer lineages are RN7SL248P, LINC01794, and AATF. Each is linked with NNMT in more than 2 cancer types. Because this analysis shows association rather than direction, both NNMT-to-partner and partner-to-NNMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by NNMT-low versus NNMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NNMT→partner) and Y-score (partner→NNMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.066	+3.307	<.001	.003	3	3
COAD	LINC01794 →	+0.135	+6.734	<.001	<.001	3	2
UCEC	AATF →	+0.468	+4.169	.001	<.001	3	2
UCEC	MYO19 →	+0.530	+3.831	.001	<.001	3	2
UCEC	GOLGA6L10 →	+0.190	+2.688	.009	.004	3	2
SKCM	LINC00674 →	+0.674	+3.478	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,446 associations by consensus.

RN7SL248P by NNMT expression — UCEC

Explore this box plot interactively →