NNMT

Across TCGA pan-cancer cohorts, NNMT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated NNMT data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher NNMT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NNMT expression acts as an unfavorable survival marker, although some lineages such as SKCM and DLBC show a favorable association.

STAD, LUSC, and LGG are the cancer types where NNMT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Quartile	All	0.366	0.662	.003	72	view →
LUSC	DFS	Tertile	II,III,IV	0.253	0.443	.004	54	view →
LGG	DFS	Median	All	0.636	0.841	<.001	54	view →
HNSC	OS	Median	All	0.313	0.490	<.001	43	view →
SKCM	OS	Quartile	III,IV	0.626	0.164	<.001	42	view →
DLBC	DFS	Quartile	All	1.000	0.569	.009	30	view →
LUAD	DFS	Quartile	III,IV	0.294	0.770	<.001	24	view →
LIHC	OS	Tertile	II,III,IV	0.719	0.483	.002	24	view →
MESO	OS	Median	All	0.709	0.311	.013	23	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	18	view →
LAML	DFS	Tertile	All	0.475	0.247	.011	12	view →
UVM	OS	Tertile	II,III,IV	0.757	0.931	.019	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

NNMT–STAD (OS)

Open the STAD breakdown →