NME1-NME2

Across TCGA patient cohorts, NME1-NME2 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,121 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible NME1-NME2-associated GO terms across cancer lineages are L-proline biosynthetic process, Complement activation, and Antibacterial humoral response. Each is linked with NME1-NME2 in more than 20 cancer types. Because this analysis shows association rather than direction, both NME1-NME2-to-partner and partner-to-NME1-NME2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, L-proline biosynthetic process grouped by NME1-NME2-low versus NME1-NME2-high in SARC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NME1-NME2→partner) and Y-score (partner→NME1-NME2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	L-proline biosynthetic process →	+0.060	+0.416	<.001	<.001	3	21
ESCA	Complement activation →	-0.087	-0.396	<.001	.002	3	20
SCLC	Antibacterial humoral response →	-0.127	-0.858	.001	.002	2	20
THYM	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.139	+0.652	<.001	<.001	3	19
THYM	Mitotic chromosome condensation →	+0.125	+0.727	<.001	<.001	3	19
TGCT	Humoral immune response →	-0.049	-0.583	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,121 associations by consensus.

L-proline biosynthetic process by NME1-NME2 expression — SARC

Explore this box plot interactively →