NLRP4

Across TCGA cell cohorts, NLRP4 mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NLRP4-associated genes across cancer lineages are KRTAP2-1, ODF1, and OR11H6. Each is linked with NLRP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRP4-to-partner and partner-to-NLRP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP2-1 grouped by NLRP4-low versus NLRP4-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP4→partner) and Y-score (partner→NLRP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KRTAP2-1 →	+0.045	+4.491	.003	.003	3	2
CNS	ODF1 →	+0.033	+3.302	<.001	.003	3	2
CNS	OR11H6 →	+0.021	+3.906	<.001	.001	3	2
CNS	SERPINA11 →	+0.241	+3.302	<.001	.003	3	2
LARGE_INTESTINE	TBC1D3 →	+0.062	+2.425	<.001	.004	3	2
OESOPHAGUS	ANKRD30A →	+0.021	+2.847	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

KRTAP2-1 by NLRP4 expression — PANCREAS

Explore this box plot interactively →