NLRP4

Across TCGA pan-cancer cohorts, NLRP4 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated NLRP4 data layer compared with 10 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NLRP4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NLRP4 expression acts as an unfavorable survival marker, although some lineages such as UCS and CHOL show a favorable association.

ACC, OV, and THCA are the cancer types where NLRP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.403	0.821	<.001	81	view →
OV	OS	Tertile	III,IV	0.785	0.875	.001	54	view →
THCA	DFS	Tertile	II,III,IV	0.722	0.920	.009	29	view →
UCS	DFS	Tertile	II,III,IV	0.571	0.159	.007	22	view →
CHOL	OS	Tertile	II,III,IV	1.000	0.504	.024	14	view →
THYM	OS	Median	II,III,IV	0.976	0.688	.008	10	view →
KIRC	DFS	Median	All	0.894	0.831	.023	7	view →
LUSC	DFS	Median	III,IV	0.438	0.927	.009	6	view →
UCEC	DFS	Quartile	All	0.764	0.846	.018	6	view →
MESO	DFS	Median	III,IV	0.313	0.500	.013	6	view →
BLCA	DFS	Quartile	II,III,IV	0.227	0.381	.033	5	view →
SKCM	DFS	Median	All	0.260	0.154	.007	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

NLRP4–ACC (OS)

Open the ACC breakdown →