NLRP13

Across TCGA patient cohorts, NLRP13 mutation is significantly associated with the RNA expression of many other genes, with 4,169 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP13-associated genes across cancer lineages are LMNB2, POLE2, and C1QBP. Each is linked with NLRP13 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRP13-to-partner and partner-to-NLRP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LMNB2 grouped by NLRP13-low versus NLRP13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP13→partner) and Y-score (partner→NLRP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LMNB2 →	+0.596	+2.790	<.001	<.001	3	4
UCEC	POLE2 →	+0.392	+1.787	.003	.007	3	4
UCEC	C1QBP →	+0.446	+2.364	<.001	<.001	3	4
UCEC	NDUFC1 →	+0.291	+2.119	.003	<.001	3	4
UCEC	PSMD9 →	+0.272	+1.753	.005	.004	3	4
UCEC	MON1A →	+0.407	+1.736	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,169 associations by consensus.

LMNB2 by NLRP13 expression — UCEC

Explore this box plot interactively →