NLRP13

Across TCGA pan-cancer cohorts, NLRP13 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated NLRP13 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher NLRP13 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NLRP13 expression acts as an unfavorable survival marker, although some lineages such as CHOL and LUSC show a favorable association.

UCS, KIRC, and DLBC are the cancer types where NLRP13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	All	0.218	0.628	<.001	126	view →
KIRC	OS	Tertile	All	0.531	0.671	.002	64	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.017	25	view →
ACC	DFS	Tertile	III,IV	0.226	0.700	<.001	24	view →
TGCT	DFS	Quartile	II,III,IV	0.586	0.996	.007	18	view →
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	9	view →
CHOL	OS	Median	IV	1.000	0.286	.024	9	view →
SKCM	DFS	Quartile	IV	0.016	0.623	.025	9	view →
LUSC	OS	Tertile	III,IV	0.601	0.301	.043	9	view →
SCLC	DFS	Tertile	All	0.275	0.754	.006	6	view →
THCA	OS	Tertile	III,IV	0.639	0.930	.032	6	view →
ESCA	DFS	Median	II,III,IV	0.434	0.587	.032	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

NLRP13–UCS (OS)

Open the UCS breakdown →