NLRP13

Across TCGA pan-cancer cohorts, NLRP13 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of NLRP13’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where NLRP13 RNA is repressed in tumor relative to normal tissue. In most cancer types NLRP13 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

BRCA, PRAD, and LUSC are the cancer types where NLRP13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NLRP13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	II,III,IV	−0.301	<.001	6	view →
PRAD	All	All	+0.124	<.001	2	view →
LUSC	Female	All	+0.012	.006	2	view →
KIRC	Male	All	+0.003	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

NLRP13–BRCA

Open the BRCA breakdown →