NLRP13

Across TCGA patient cohorts, NLRP13 mutation is significantly associated with the total protein of many other genes, with 72 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRP13-associated genes across cancer lineages are Chk1, PCNA, and Cyclin-B1. Each is linked with NLRP13 in more than 4 cancer types. Because this analysis shows association rather than direction, both NLRP13-to-partner and partner-to-NLRP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk1 grouped by NLRP13-low versus NLRP13-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP13→partner) and Y-score (partner→NLRP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Chk1 →	+0.114	+1.150	.020	.022	3	5
LUAD	PCNA →	+0.200	+2.182	.002	.033	3	4
LUAD	Cyclin-B1 →	+0.588	+3.459	.002	.005	3	4
LUSC	NF-kB-p65_pS536 →	-0.296	-3.000	.021	.033	3	4
UCEC	ATM →	-0.443	-1.765	.001	.013	3	4
LUAD	Thymidilate-Synthase →	+0.215	+2.335	.013	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

Chk1 by NLRP13 expression — SKCM

Explore this box plot interactively →