NLRP13

Across TCGA cell cohorts, NLRP13 mutation is significantly associated with the RNA expression of many other genes, with 379 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRP13-associated genes across cancer lineages are FZD3, PLA2G2E, and ACTL8. Each is linked with NLRP13 in more than 2 cancer types. Because this analysis shows association rather than direction, both NLRP13-to-partner and partner-to-NLRP13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FZD3 grouped by NLRP13-low versus NLRP13-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRP13→partner) and Y-score (partner→NLRP13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FZD3 →	+0.838	+3.067	<.001	.009	3	3
OESOPHAGUS	PLA2G2E →	+0.285	+4.392	<.001	.003	3	2
LUNG_NSCLC_LUAD	ACTL8 →	+0.626	+3.415	<.001	.003	3	2
LARGE_INTESTINE	LOXL3 →	+0.588	+3.169	.006	.009	3	2
LARGE_INTESTINE	MRPL37 →	+0.576	+2.714	<.001	.002	3	2
LARGE_INTESTINE	HDAC1 →	+0.614	+3.743	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 379 associations by consensus.

FZD3 by NLRP13 expression — LARGE_INTESTINE

Explore this box plot interactively →