NLRC4

Across TCGA patient cohorts, NLRC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,900 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NLRC4-associated proteins across cancer lineages are TYROBP, WAS, and WIPF1. Each is linked with NLRC4 in more than 9 cancer types. Because this analysis shows association rather than direction, both NLRC4-to-partner and partner-to-NLRC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NLRC4 versus TYROBP in CCRCC, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRC4→partner) and Y-score (partner→NLRC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TYROBP →	+0.619	+0.446	<.001	<.001	3	10
GBM	WAS →	+0.774	+0.834	<.001	<.001	3	10
GBM	WIPF1 →	+0.418	+0.757	<.001	<.001	3	10
GBM	PTPN6 →	+0.768	+0.812	<.001	<.001	3	10
OV	RASAL3 →	+0.521	+0.528	<.001	<.001	3	10
GBM	PARVG →	+0.780	+0.764	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,900 associations by consensus.

NLRC4 vs TYROBP — CCRCC

Explore this scatter interactively →