NLRC4

Across TCGA pan-cancer cohorts, NLRC4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NLRC4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NLRC4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NLRC4 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, HNSC, and LUAD are the cancer types where NLRC4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NLRC4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	+1.470	<.001	12	view →
HNSC	Female	All	+0.487	<.001	10	view →
LUAD	Female	III,IV	−1.994	<.001	9	view →
THCA	All	II,III,IV	+0.414	<.001	9	view →
LUSC	Male	II,III,IV	−2.267	<.001	8	view →
STAD	Female	All	+0.874	<.001	8	view →
KICH	All	All	−0.342	.008	3	view →
PAAD	All	All	−1.512	.015	2	view →
ESCA	All	II,III,IV	+0.795	.016	2	view →
CHOL	All	All	+0.497	.032	2	view →
KIRP	All	All	+0.367	.007	2	view →
COAD	All	All	−0.203	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NLRC4–KIRC

Open the KIRC breakdown →