NLRC4

Across TCGA pan-cancer cohorts, NLRC4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated NLRC4 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher NLRC4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NLRC4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

ACC, SKCM, and KIRP are the cancer types where NLRC4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.176	0.891	<.001	112	view →
SKCM	OS	Median	All	0.444	0.218	<.001	99	view →
KIRP	DFS	Quartile	III,IV	0.404	0.832	.001	92	view →
HNSC	DFS	Median	III,IV	0.683	0.497	<.001	90	view →
UVM	DFS	Tertile	II,III,IV	0.281	0.702	.001	75	view →
LGG	DFS	Median	All	0.270	0.511	<.001	53	view →
UCS	DFS	Tertile	III,IV	0.571	0.225	.011	42	view →
KIRC	DFS	Median	II,III,IV	0.631	0.358	.002	36	view →
STAD	OS	Quartile	All	0.431	0.797	.005	33	view →
LUAD	OS	Quartile	All	0.867	0.738	.001	29	view →
LIHC	OS	Median	III,IV	0.412	0.775	<.001	27	view →
SCLC	OS	Tertile	IV	0.137	0.556	.025	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

NLRC4–ACC (DFS)

Open the ACC breakdown →