NLRC4

Across TCGA patient cohorts, NLRC4 mutation is significantly associated with the RNA expression of many other genes, with 4,506 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLRC4-associated genes across cancer lineages are CHAC1, UBE2M, and EHMT1. Each is linked with NLRC4 in more than 3 cancer types. Because this analysis shows association rather than direction, both NLRC4-to-partner and partner-to-NLRC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHAC1 grouped by NLRC4-low versus NLRC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRC4→partner) and Y-score (partner→NLRC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHAC1 →	+0.557	+1.595	<.001	<.001	3	4
UCEC	UBE2M →	+0.261	+1.999	.002	.002	3	4
UCEC	EHMT1 →	+0.376	+1.606	<.001	<.001	3	3
UCEC	C19orf54 →	+0.303	+1.625	<.001	.002	3	3
UCEC	SLC35F6 →	+0.399	+3.180	<.001	<.001	3	3
UCEC	NEURL4 →	+0.308	+1.994	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,506 associations by consensus.

CHAC1 by NLRC4 expression — UCEC

Explore this box plot interactively →