NLRC4

Across TCGA cell cohorts, NLRC4 mutation is significantly associated with the RNA expression of many other genes, with 273 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NLRC4-associated genes across cancer lineages are IQCF3, TRIM42, and COX4I2. Each is linked with NLRC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NLRC4-to-partner and partner-to-NLRC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF3 grouped by NLRC4-low versus NLRC4-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLRC4→partner) and Y-score (partner→NLRC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IQCF3 →	+0.085	+4.781	<.001	.003	3	1
CNS	TRIM42 →	+0.004	+4.321	<.001	.009	3	1
LUNG_NSCLC_LUAD	COX4I2 →	+0.047	+3.813	<.001	.001	3	1
LUNG_NSCLC_LUAD	IDI2 →	+0.026	+3.299	<.001	.003	3	1
LARGE_INTESTINE	PPIL2 →	+0.536	+3.212	.007	.006	3	1
LARGE_INTESTINE	TOMM22 →	+0.634	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 273 associations by consensus.

IQCF3 by NLRC4 expression — BREAST

Explore this box plot interactively →