Across TCGA pan-cancer cohorts, NLGN1-AS1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NLGN1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NLGN1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NLGN1-AS1 is over-expressed in tumor.

KIRC and KIRP are the cancer types where NLGN1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NLGN1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.140	<.001	11	view →
KIRP	Male	All	+0.035	.004	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: NLGN1-AS1 RNA expression & survival · all NLGN1-AS1 data types