Q-omics provides the consensus-scored NLGN1-AS1 profile across patient tissues and cancer cell-line models. NLGN1-AS1 expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in THCA. Among the 18 cancer types available for tumor–normal comparison, NLGN1-AS1 is differentially expressed in 2, with the highest sampling consensus in KIRC. Additionally, NLGN1-AS1 RNA expression shows 11,583 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight THCA, KIRC, and GBM as cancer lineages where NLGN1-AS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NLGN1-AS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NLGN1-AS1 survival associations across molecular data types. NLGN1-AS1 RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NLGN1-AS1 RNA expression–survival associations across cancer types. High NLGN1-AS1 expression shows unfavorable associations in THCA, LUAD, HNSC and STAD, but favorable associations in OV and LAML. The THCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THCA as the clearest survival context for NLGN1-AS1 RNA expression.
This table summarizes NLGN1-AS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in KIRC for RNA.
This table ranks reproducible tumor–normal expression differences for NLGN1-AS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NLGN1-AS1 shows higher tumor expression in KIRC and KIRP. The KIRC box plot shows higher NLGN1-AS1 RNA expression in tumor versus normal tissue (log2 FC = +0.140, t-test p < 0.001).
This table shows molecular features associated with NLGN1-AS1 in patient tissues and cancer cell lines. In patient samples, NLGN1-AS1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set.
