NLE1

Across TCGA patient cohorts, NLE1 mutation is significantly associated with the RNA expression of many other genes, with 664 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NLE1-associated genes across cancer lineages are RNA5SP331, WDR76, and MIR6783. Each is linked with NLE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both NLE1-to-partner and partner-to-NLE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP331 grouped by NLE1-low versus NLE1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NLE1→partner) and Y-score (partner→NLE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNA5SP331 →	+0.245	+5.226	<.001	.003	3	3
UCEC	WDR76 →	+0.842	+2.684	<.001	<.001	3	3
SKCM	MIR6783 →	+0.410	+2.609	.004	.009	3	2
LUAD	MIR101-1 →	+0.612	+4.399	.001	.006	3	2
UCEC	PACSIN2 →	+0.395	+2.906	.008	.001	3	2
UCEC	KCTD9 →	+0.615	+2.180	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 664 associations by consensus.

RNA5SP331 by NLE1 expression — STAD

Explore this box plot interactively →