NLE1

Across TCGA pan-cancer cohorts, NLE1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of NLE1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NLE1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NLE1 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, COAD, and KIRP are the cancer types where NLE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NLE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+0.811	<.001	12	view →
COAD	Male	IV	+1.643	<.001	11	view →
KIRP	All	II,III,IV	+0.906	<.001	11	view →
BLCA	All	III,IV	+0.751	<.001	10	view →
LIHC	Male	II,III,IV	+1.214	<.001	9	view →
STAD	Male	II,III,IV	+1.189	<.001	9	view →
LUAD	Male	All	+0.877	<.001	9	view →
LUSC	Male	II,III,IV	+1.193	<.001	8	view →
HNSC	Male	All	+0.697	<.001	8	view →
READ	All	All	+1.062	<.001	7	view →
CHOL	Female	All	+2.586	<.001	5	view →
KICH	Female	All	−0.977	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

NLE1–KIRC

Open the KIRC breakdown →