NKX6-3

Across TCGA patient cohorts, NKX6-3 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,860 significant associations in total. LGG shows the largest number of these associations.

The most reproducible NKX6-3-associated GO terms across cancer lineages are Positive regulation of DNA metabolic process, Positive regulation of DNA repair, and Base-excision repair. Each is linked with NKX6-3 in more than 13 cancer types. Because this analysis shows association rather than direction, both NKX6-3-to-partner and partner-to-NKX6-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA metabolic process grouped by NKX6-3-low versus NKX6-3-high in HNSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX6-3→partner) and Y-score (partner→NKX6-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	Positive regulation of DNA metabolic process →	+0.025	+0.200	<.001	<.001	3	14
TGCT	Positive regulation of DNA repair →	+0.029	+1.664	<.001	<.001	3	13
LAML	Base-excision repair →	+0.027	+0.092	<.001	.001	3	13
HNSC	ATP synthesis coupled electron transport →	+0.036	+0.224	<.001	.002	3	13
HNSC	Mitochondrial gene expression →	+0.024	+0.168	<.001	<.001	3	12
LUSC	U2-type prespliceosome assembly →	+0.038	+0.389	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,860 associations by consensus.

Positive regulation of DNA metabolic process by NKX6-3 expression — HNSC

Explore this box plot interactively →