NKX6-1

Across TCGA patient cohorts, NKX6-1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,228 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible NKX6-1-associated proteins across cancer lineages are MAP1B, MAP1B_S2271, and GAP43. Each is linked with NKX6-1 in more than 4 cancer types. Because this analysis shows association rather than direction, both NKX6-1-to-partner and partner-to-NKX6-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NKX6-1 versus MAP1B in LSCC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX6-1→partner) and Y-score (partner→NKX6-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B →	+0.987	+0.413	<.001	<.001	3	5
LSCC	MAP1B_S2271 →	+1.084	+0.355	<.001	<.001	3	5
LUAD	GAP43 →	+1.104	+0.235	<.001	.006	3	4
OV	MAP2 →	+0.550	+1.169	.005	.003	3	4
BRCA	STIM1 →	-0.324	-0.851	.001	<.001	3	4
LSCC	NOL9 →	+0.292	+0.428	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,228 associations by consensus.

NKX6-1 vs MAP1B — LSCC

Explore this scatter interactively →