NKX6-1

Across TCGA patient cohorts, NKX6-1 protein abundance is significantly associated with the RNA expression of many other genes, with 526 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NKX6-1-associated genes across cancer lineages are CYP20A1, FAR2P3, and RAPGEF6. Each is linked with NKX6-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX6-1-to-partner and partner-to-NKX6-1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NKX6-1 versus CYP20A1 in GBM, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX6-1→partner) and Y-score (partner→NKX6-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYP20A1 →	+0.365	+1.336	.002	.001	3	2
GBM	FAR2P3 →	+0.762	+1.204	.003	.001	3	2
OV	RAPGEF6 →	+0.415	+0.379	<.001	.001	3	1
OV	SLFN12 →	+0.484	+0.379	.001	.001	3	1
OV	H3P16 →	-1.959	-0.379	.003	.001	3	1
OV	H3P47 →	-3.050	-0.379	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 526 associations by consensus.

NKX6-1 vs CYP20A1 — GBM

Explore this scatter interactively →