NKX6-1

Across TCGA patient cohorts, NKX6-1 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. READ shows the largest number of these associations.

The most reproducible NKX6-1-associated genes across cancer lineages are Th2 cells, DC, and Astrocytes. Each is linked with NKX6-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX6-1-to-partner and partner-to-NKX6-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Th2 cells grouped by NKX6-1-low versus NKX6-1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX6-1→partner) and Y-score (partner→NKX6-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Th2 cells →	+0.267	+3.010	.002	.019	3	2
READ	DC →	+0.022	+3.231	.039	.044	3	1
READ	Astrocytes →	+0.056	+3.157	.023	.049	3	1
UCEC	MEP →	+0.041	+3.595	.002	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Th2 cells by NKX6-1 expression — UCEC

Explore this box plot interactively →