NKX6-1

Across TCGA cell cohorts, NKX6-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,844 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NKX6-1-associated GO terms across cancer lineages are Positive regulation of type B pancreatic cell development, Type B pancreatic cell proliferation, and Regulation of translational initiation. Each is linked with NKX6-1 in more than 12 cancer types. Because this analysis shows association rather than direction, both NKX6-1-to-partner and partner-to-NKX6-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of type B pancreatic cell development grouped by NKX6-1-low versus NKX6-1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX6-1→partner) and Y-score (partner→NKX6-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of type B pancreatic cell development →	-0.193	-0.909	<.001	<.001	3	13
OESOPHAGUS	Type B pancreatic cell proliferation →	-0.291	-0.608	<.001	.001	3	12
OESOPHAGUS	Regulation of translational initiation →	+0.076	+0.631	<.001	<.001	3	10
OESOPHAGUS	Protein localization to nucleus →	+0.075	+0.661	<.001	.001	3	10
OESOPHAGUS	Regulation of stem cell population maintenance →	+0.100	+0.751	<.001	.002	3	10
OESOPHAGUS	Regulation of neurotransmitter secretion →	-0.110	-0.653	.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,844 associations by consensus.

Positive regulation of type B pancreatic cell development by NKX6-1 expression — BREAST

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