NKX6-1

Across TCGA cell cohorts, NKX6-1 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NKX6-1-associated genes across cancer lineages are Wee1 Inhibitor, AZD1208, and LCL161. Each is linked with NKX6-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX6-1-to-partner and partner-to-NKX6-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Wee1 Inhibitor grouped by NKX6-1-low versus NKX6-1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX6-1→partner) and Y-score (partner→NKX6-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Wee1 Inhibitor →	+0.566	+2.932	.023	.009	3	1
LARGE_INTESTINE	AZD1208 →	+0.349	+2.871	.033	.021	3	1
LARGE_INTESTINE	LCL161 →	+0.451	+2.710	.002	.027	3	1
LARGE_INTESTINE	CZC24832 →	+0.327	+2.868	.007	.022	3	1
LARGE_INTESTINE	Teniposide →	+0.499	+2.871	.049	.021	3	1
LARGE_INTESTINE	AZD6738 →	+0.533	+2.871	.032	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Wee1 Inhibitor by NKX6-1 expression — LARGE_INTESTINE

Explore this box plot interactively →