NKX3-1

Across TCGA patient cohorts, NKX3-1 mutation is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX3-1-associated genes across cancer lineages are OR51L1, RPL21P47, and RNU6-347P. Each is linked with NKX3-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX3-1-to-partner and partner-to-NKX3-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51L1 grouped by NKX3-1-low versus NKX3-1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX3-1→partner) and Y-score (partner→NKX3-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	OR51L1 →	+0.083	+6.014	<.001	<.001	3	2
LUAD	RPL21P47 →	+0.122	+5.000	<.001	.003	3	2
PRAD	RNU6-347P →	+0.263	+7.939	<.001	.008	3	2
SKCM	RN7SL853P →	+0.124	+5.485	<.001	.001	3	2
PRAD	RNA5SP326 →	+0.583	+7.939	<.001	.008	3	1
PRAD	RNA5SP189 →	+0.242	+7.939	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

OR51L1 by NKX3-1 expression — LUAD

Explore this box plot interactively →