NKX3-1

Across TCGA pan-cancer cohorts, NKX3-1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated NKX3-1 data layer compared with 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher NKX3-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated NKX3-1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and PRAD show a favorable association.

LUAD, MESO, and BRCA are the cancer types where NKX3-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.614	0.751	.005	70	view →
MESO	OS	Median	II,III,IV	0.261	0.523	<.001	60	view →
BRCA	DFS	Tertile	IV	0.810	0.351	.002	43	view →
GBM	OS	Median	All	0.313	0.513	<.001	36	view →
KIRC	OS	Tertile	II,III,IV	0.443	0.650	.006	31	view →
THCA	OS	Tertile	II,III,IV	0.767	0.958	.008	30	view →
PAAD	DFS	Quartile	All	0.128	0.576	.006	20	view →
THYM	OS	Median	II,III,IV	0.673	0.936	.002	14	view →
BLCA	DFS	Quartile	All	0.228	0.591	.006	12	view →
UCS	OS	Tertile	IV	0.306	0.761	.024	12	view →
PRAD	DFS	Tertile	All	0.942	0.855	.004	12	view →
READ	OS	Median	IV	0.824	0.466	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

NKX3-1–LUAD (DFS)

Open the LUAD breakdown →