NKX3-1

Across TCGA pan-cancer cohorts, NKX3-1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NKX3-1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where NKX3-1 RNA is repressed in tumor relative to normal tissue. In most cancer types NKX3-1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, KIRC, and LIHC are the cancer types where NKX3-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NKX3-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−1.107	<.001	8	view →
KIRC	All	All	−0.376	<.001	6	view →
LIHC	Female	All	−0.733	<.001	5	view →
THCA	Female	All	−0.717	<.001	5	view →
PRAD	All	All	+1.498	<.001	2	view →
COAD	Female	IV	−0.450	.034	2	view →
READ	Female	All	−0.976	.014	1	view →
CHOL	Female	All	−0.463	.031	1	view →
LUAD	All	All	−0.288	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NKX3-1–KICH

Open the KICH breakdown →