NKX3-1

Across TCGA cell cohorts, NKX3-1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,910 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible NKX3-1-associated GO terms across cancer lineages are Protein lipidation, Regulation of plasminogen activation, and Peptidyl-lysine oxidation. Each is linked with NKX3-1 in more than 12 cancer types. Because this analysis shows association rather than direction, both NKX3-1-to-partner and partner-to-NKX3-1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein lipidation grouped by NKX3-1-low versus NKX3-1-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX3-1→partner) and Y-score (partner→NKX3-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Protein lipidation →	+0.105	+0.770	<.001	.001	3	13
SOFT_TISSUE	Regulation of plasminogen activation →	+0.295	+1.465	<.001	<.001	3	12
STOMACH	Peptidyl-lysine oxidation →	+1.626	+1.482	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of hemostasis →	+0.343	+1.794	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of blood coagulation →	+0.343	+1.794	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of coagulation →	+0.330	+1.794	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,910 associations by consensus.

Protein lipidation by NKX3-1 expression — PANCREAS

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