NKX2-8

Across TCGA patient cohorts, NKX2-8 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,074 significant associations in total. LIHC shows the largest number of these associations.

The most reproducible NKX2-8-associated GO terms across cancer lineages are Negative regulation of release of cytochrome c from mitochondria, 5-phosphoribose 1-diphosphate metabolic process, and Protein insertion into ER membrane by stop-transfer membrane-anchor sequence. Each is linked with NKX2-8 in more than 12 cancer types. Because this analysis shows association rather than direction, both NKX2-8-to-partner and partner-to-NKX2-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of release of cytochrome c from mitochondria grouped by NKX2-8-low versus NKX2-8-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-8→partner) and Y-score (partner→NKX2-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Negative regulation of release of cytochrome c from mitochondria →	+0.054	+0.947	<.001	<.001	3	13
THYM	5-phosphoribose 1-diphosphate metabolic process →	+0.090	+0.857	<.001	<.001	3	12
TGCT	Protein insertion into ER membrane by stop-transfer membrane-anchor sequence →	+0.041	+0.682	<.001	<.001	3	12
THYM	Loop of Henle development →	+0.088	+0.904	<.001	<.001	3	11
TGCT	Negative regulation of protein targeting to membrane →	+0.062	+0.667	<.001	<.001	3	11
ESCA	Regulation of epidermis development →	+0.045	+0.982	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,074 associations by consensus.

Negative regulation of release of cytochrome c from mitochondria by NKX2-8 expression — TGCT

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