NKX2-8

Across TCGA patient cohorts, NKX2-8 mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. STAD shows the largest number of these associations.

The most reproducible NKX2-8-associated genes across cancer lineages are Osteoblast and lymphatic Endothelial cells. Each is linked with NKX2-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-8-to-partner and partner-to-NKX2-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Osteoblast grouped by NKX2-8-low versus NKX2-8-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-8→partner) and Y-score (partner→NKX2-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Osteoblast →	+0.036	+3.669	.002	.049	3	1
UCEC	lymphatic Endothelial cells →	-0.026	-3.268	.038	.011	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

Osteoblast by NKX2-8 expression — STAD

Explore this box plot interactively →