NKX2-8

Across TCGA cell cohorts, NKX2-8 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,080 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible NKX2-8-associated GO terms across cancer lineages are Cell fate specification, Mitochondrion organization, and Protein-RNA complex organization. Each is linked with NKX2-8 in more than 8 cancer types. Because this analysis shows association rather than direction, both NKX2-8-to-partner and partner-to-NKX2-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell fate specification grouped by NKX2-8-low versus NKX2-8-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-8→partner) and Y-score (partner→NKX2-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Cell fate specification →	-0.080	-0.668	<.001	<.001	3	9
OESOPHAGUS	Mitochondrion organization →	+0.067	+1.518	<.001	<.001	3	8
OESOPHAGUS	Protein-RNA complex organization →	+0.112	+1.481	<.001	<.001	3	8
PANCREAS	Regulation of protein localization to nucleus →	+0.063	+0.549	.001	.007	3	8
OESOPHAGUS	Protein-RNA complex assembly →	+0.110	+1.481	<.001	<.001	3	8
OESOPHAGUS	Spliceosomal snRNP assembly →	+0.100	+1.512	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,080 associations by consensus.

Cell fate specification by NKX2-8 expression — OVARY

Explore this box plot interactively →