NKX2-8

Across TCGA cell cohorts, NKX2-8 mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NKX2-8-associated genes across cancer lineages are MT1HL1. Each is linked with NKX2-8 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-8-to-partner and partner-to-NKX2-8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MT1HL1 grouped by NKX2-8-low versus NKX2-8-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-8→partner) and Y-score (partner→NKX2-8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MT1HL1 →	+0.173	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

MT1HL1 by NKX2-8 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →