NKX2-6

Across TCGA patient cohorts, NKX2-6 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,096 significant associations in total. STAD shows the largest number of these associations.

The most reproducible NKX2-6-associated GO terms across cancer lineages are Positive regulation of mitotic cell cycle, Regulation of binding, and Negative regulation of binding. Each is linked with NKX2-6 in more than 9 cancer types. Because this analysis shows association rather than direction, both NKX2-6-to-partner and partner-to-NKX2-6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cell cycle grouped by NKX2-6-low versus NKX2-6-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-6→partner) and Y-score (partner→NKX2-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of mitotic cell cycle →	+0.065	+0.069	<.001	<.001	3	10
STAD	Regulation of binding →	+0.069	+0.079	<.001	<.001	3	9
STAD	Negative regulation of binding →	+0.065	+0.064	<.001	<.001	3	8
STAD	Telomerase RNA localization →	+0.074	+0.072	<.001	<.001	3	8
STAD	Carbohydrate biosynthetic process →	+0.051	+0.071	<.001	<.001	3	8
STAD	Morphogenesis of a branching structure →	+0.058	+0.053	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,096 associations by consensus.

Positive regulation of mitotic cell cycle by NKX2-6 expression — STAD

Explore this box plot interactively →