NKX2-6

Across TCGA cell cohorts, NKX2-6 RNA expression is significantly associated with the mutation status of many other genes, with 818 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NKX2-6-associated genes across cancer lineages are LAMB2, FAT1, and DIDO1. Each is linked with NKX2-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-6-to-partner and partner-to-NKX2-6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LAMB2 grouped by NKX2-6-low versus NKX2-6-high in BLOOD_Leukemia.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-6→partner) and Y-score (partner→NKX2-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LAMB2 →	+2.879	+0.158	.001	.001	3	2
BLOOD_Lymphoma	FAT1 →	+2.254	+0.172	.001	.007	3	2
LUNG_SCLC	DIDO1 →	+3.169	+0.029	.005	<.001	3	2
BLOOD_Leukemia	ZNF831 →	+3.201	+0.215	.005	<.001	3	2
BLOOD_Leukemia	NLRP12 →	+4.201	+0.362	.001	<.001	3	2
LUNG_SCLC	SLITRK5 →	+3.584	+0.034	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 818 associations by consensus.

LAMB2 by NKX2-6 expression — BLOOD_Leukemia

Explore this box plot interactively →