NKX2-6

Across TCGA cell cohorts, NKX2-6 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NKX2-6-associated genes across cancer lineages are ECE2, VAX1, and OR4F21. Each is linked with NKX2-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-6-to-partner and partner-to-NKX2-6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by NKX2-6-low versus NKX2-6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-6→partner) and Y-score (partner→NKX2-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.260	+3.376	<.001	.002	3	1
LARGE_INTESTINE	VAX1 →	+0.614	+3.410	.002	.007	3	1
LARGE_INTESTINE	OR4F21 →	+0.155	+2.878	<.001	.009	3	1
LARGE_INTESTINE	TAFA1 →	+0.234	+3.103	.002	.004	3	1
LARGE_INTESTINE	CENPVL3 →	+0.231	+3.242	<.001	.003	3	1
LARGE_INTESTINE	CPO →	+0.142	+3.514	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ECE2 by NKX2-6 expression — LARGE_INTESTINE

Explore this box plot interactively →