NKX2-5

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, NKX2-5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,474 significant associations in total. CNS shows the largest number of these associations.

The most reproducible NKX2-5-associated GO terms across cancer lineages are Positive regulation of cardioblast differentiation, Ventricular cardiac muscle cell development, and DNA-templated transcription initiation. Each is linked with NKX2-5 in more than 14 cancer types. Because this analysis shows association rather than direction, both NKX2-5-to-partner and partner-to-NKX2-5 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-5→partner) and Y-score (partner→NKX2-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUNG_SCLCPositive regulation of cardioblast differentiation →-0.342-1.921<.001<.001315
OESOPHAGUSVentricular cardiac muscle cell development →-0.224-1.453<.001.006313
BONEDNA-templated transcription initiation →+0.076+1.809.001.003310
LUNG_SCLCHis-Purkinje system development →-0.321-2.152<.001<.00139
OESOPHAGUSPositive regulation of sodium ion transport →-0.177-1.800.002.00838
LUNG_SCLCRegulation of cardioblast differentiation →-0.346-2.212<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,474 associations by consensus.

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