Across TCGA cell cohorts, NKX2-5 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NKX2-5-associated genes across cancer lineages are ACOT12, TFDP3, and LINGO4. Each is linked with NKX2-5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-5-to-partner and partner-to-NKX2-5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-5→partner) and Y-score (partner→NKX2-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ACOT12 →	+0.036	+4.479	<.001	<.001	3	1
LARGE_INTESTINE	TFDP3 →	+0.024	+2.933	<.001	.003	3	1
LARGE_INTESTINE	LINGO4 →	+0.122	+3.584	<.001	.004	3	1
LARGE_INTESTINE	F11 →	+0.039	+2.882	<.001	.005	3	1
LARGE_INTESTINE	BAAT →	+0.636	+3.273	<.001	.006	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

NKX2-5 survival (RNA) · tumor vs normal (RNA) · all NKX2-5 data types