NKX2-4

Across TCGA patient cohorts, NKX2-4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,722 significant associations in total. STAD shows the largest number of these associations.

The most reproducible NKX2-4-associated GO terms across cancer lineages are DNA conformation change, Nuclear membrane organization, and DNA-templated DNA replication. Each is linked with NKX2-4 in more than 12 cancer types. Because this analysis shows association rather than direction, both NKX2-4-to-partner and partner-to-NKX2-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA conformation change grouped by NKX2-4-low versus NKX2-4-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-4→partner) and Y-score (partner→NKX2-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	DNA conformation change →	+0.046	+0.051	<.001	<.001	3	12
STAD	Nuclear membrane organization →	+0.057	+0.057	<.001	<.001	3	12
ESCA	DNA-templated DNA replication →	+0.062	+0.117	.001	.004	1	13
STAD	mRNA export from nucleus →	+0.054	+0.051	<.001	<.001	3	11
STAD	Nucleobase-containing compound transport →	+0.052	+0.055	<.001	<.001	3	11
STAD	Methylation →	+0.045	+0.062	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,722 associations by consensus.

DNA conformation change by NKX2-4 expression — STAD

Explore this box plot interactively →