NKX2-4

Across TCGA cell cohorts, NKX2-4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,316 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NKX2-4-associated GO terms across cancer lineages are Positive regulation of DNA biosynthetic process, Mitotic cell cycle phase transition, and Cell cycle G1/S phase transition. Each is linked with NKX2-4 in more than 5 cancer types. Because this analysis shows association rather than direction, both NKX2-4-to-partner and partner-to-NKX2-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA biosynthetic process grouped by NKX2-4-low versus NKX2-4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-4→partner) and Y-score (partner→NKX2-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA biosynthetic process →	+0.094	+1.828	.001	.003	3	6
BONE	Mitotic cell cycle phase transition →	+0.066	+1.672	.001	<.001	3	5
BONE	Cell cycle G1/S phase transition →	+0.071	+1.742	.009	.002	3	5
BONE	DNA-templated transcription termination →	+0.113	+2.884	.002	<.001	3	5
BONE	Regulation of transcription by RNA polymerase I →	+0.114	+1.648	<.001	<.001	3	5
BONE	Protein-DNA complex assembly →	+0.062	+2.006	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,316 associations by consensus.

Positive regulation of DNA biosynthetic process by NKX2-4 expression — BONE

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