NKX2-4

Across TCGA cell cohorts, NKX2-4 protein abundance is significantly associated with the drug of many other genes, with 37 significant associations in total. BONE shows the largest number of these associations.

The most reproducible NKX2-4-associated genes across cancer lineages are Doxorubicin, Bleomycin (10 uM), and AZD4877. Each is linked with NKX2-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-4-to-partner and partner-to-NKX2-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Doxorubicin grouped by NKX2-4-low versus NKX2-4-high in BONE.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-4→partner) and Y-score (partner→NKX2-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Doxorubicin →	+0.910	+1.329	.017	.006	3	1
BONE	Bleomycin (10 uM) →	+1.540	+1.349	.033	.009	3	1
BONE	AZD4877 →	+0.945	+1.376	.001	<.001	3	1
BONE	FGFR_0939 →	+0.723	+1.026	.004	.045	3	1
BONE	AZD7969 →	+0.599	+1.329	.043	.006	3	1
BONE	PARP_9482 →	+0.459	+1.329	.048	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Doxorubicin by NKX2-4 expression — BONE

Explore this box plot interactively →