NKX2-4

Across TCGA cell cohorts, NKX2-4 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible NKX2-4-associated genes across cancer lineages are OR4K2 and TBL1Y. Each is linked with NKX2-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-4-to-partner and partner-to-NKX2-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4K2 grouped by NKX2-4-low versus NKX2-4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-4→partner) and Y-score (partner→NKX2-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR4K2 →	+0.025	+4.384	<.001	.006	3	1
BLOOD_Leukemia	TBL1Y →	+0.644	+3.744	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR4K2 by NKX2-4 expression — BLOOD_Leukemia

Explore this box plot interactively →