NKX2-3

Across TCGA patient cohorts, NKX2-3 mutation is significantly associated with the RNA expression of many other genes, with 368 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX2-3-associated genes across cancer lineages are SUMO2P12, RNU6ATAC29P, and TRIM51EP. Each is linked with NKX2-3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-3-to-partner and partner-to-NKX2-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUMO2P12 grouped by NKX2-3-low versus NKX2-3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-3→partner) and Y-score (partner→NKX2-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SUMO2P12 →	+0.282	+5.103	<.001	.008	3	2
BLCA	RNU6ATAC29P →	+0.445	+5.038	<.001	.009	3	2
BLCA	TRIM51EP →	+0.120	+5.106	<.001	.008	3	2
UCEC	NUTF2P8 →	+0.169	+3.175	<.001	.002	3	2
UCEC	MIR6803 →	+0.251	+5.308	<.001	.001	3	2
UCEC	RPL17P14 →	+0.076	+3.356	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 368 associations by consensus.

SUMO2P12 by NKX2-3 expression — CESC

Explore this box plot interactively →