NKX2-3

Across TCGA patient cohorts, NKX2-3 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NKX2-3-associated genes across cancer lineages are GATA6, JNK2, and MAPK_pT202_Y204. Each is linked with NKX2-3 in more than 1 cancer types. Because this analysis shows association rather than direction, both NKX2-3-to-partner and partner-to-NKX2-3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by NKX2-3-low versus NKX2-3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NKX2-3→partner) and Y-score (partner→NKX2-3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.228	-3.162	.007	.019	3	2
UCEC	JNK2 →	+0.304	+3.321	.003	.010	3	1
UCEC	MAPK_pT202_Y204 →	+0.527	+3.321	.032	.010	3	1
UCEC	MEK1_p_S217_S221 →	+0.396	+3.000	.005	.036	3	1
UCEC	mTOR →	-0.235	-3.321	.005	.010	3	1
UCEC	PRAS40_pT246 →	+0.227	+3.169	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GATA6 by NKX2-3 expression — UCEC

Explore this box plot interactively →